Meccanismi comuni tra diabete e declino cognitivo

The increased prevalence of diabetes (DM) constitutes a major public health problem, primarily due to its numerous comorbidity and complications. It is widely demonstrated that DM significant risk factor for the development cognitive impairment. Metabolic diseases can influence functions through multiple interconnected mechanisms. Cerebral insulin resistance, oxidative stress, neuroinflammation, neuroendocrine dysfunctions further neurodegeneration diseases. identification molecular mechanisms involved represents target founding early potential markers new therapeutic targets neurodegenerative